SPEAKERS

Rapid NMR Method for the Assignment of Regioisomers in Monosubstituted 1,2,3-Thiadiazoles

Carlos Amezcua is the Structure Elucidation group leader at FMC Corporation. His group uses NMR spectroscopy and other analytical techniques to verify molecular structures, determine purities, isolate and identify impurities and understand chemical reactions in support of FMC’s products.

NMR Solution Conformational Analysis and Its Application to Drug Design

Guoyun received her PhD in Analytical Chemistry from Wuhan Institute of Physics and Mathematics, China. She started her career in pharmaceutical industry at Pfizer as an NMR specialist and currently leads the US analytical chemistry group supporting discovery chemistry at Janssen R&D.

NMR at USP: Applications in USP-NF (History, General Chapters, Monographs) and USP Reference Standards Evaluation

Dr. Edmond Biba is a Principal Scientist in the General Chapters Department-Science Division at United States Pharmacopeial Convention. He serves as scientific liaison to the USP General Chapters-Chemical Analysis Expert Committee and USP General Chapters-Physical Analysis Expert Committee. Since joining USP in 2001, Dr. Biba served as a scientist in the Research and Development Laboratory and in the Reference Standards Evaluation Department. Dr. Biba received his Ph.D. in Chemistry-Synthetic Organic Chemistry from the American University, Washington DC, and a B.Sc./M.Sc. in Chemical Engineering/Chemistry from University of Tirana, Tirana, Albania.

Identification and Quantification of Natural and Engineered Metabolites

Brendan M. Duggan has over 30 years of experience applying NMR to small molecules, proteins, nucleic acids and polymers. His interests involve using NMR to determine molecular structures, monitor interactions, and characterize dynamics, as well as applying machine learning to the NMR analysis of metabolites. Brendan currently acts as the Director of the NMR Facility at the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego.

Revisiting Bayesian Computational Tools and Applications to Small Molecules

Dr. Eghbalnia received a PhD in mathematics from UW-Madison and a Masters Degree in Biomedical Engineering from UC San Diego. His research has been focused on inferential and computational molecular/biomolecular methods and biomarker discovery.

Impacting Drug Design using NMR Solution Conformations

Kathleen Farley is a Senior Principal Scientist at Pfizer Inc with over 30 years of experience in applying NMR spectroscopy to Drug Discovery. She has taught the American Chemical Society (ACS) 2D NMR course for the last 10 years. Her research includes the structural characterization of small molecules/peptides using residual dipolar couplings.

HIF-2 inhibitors: Examples of the versatility of NMR in drug discovery

Kevin is director of the Structural Biology Initiative of the CUNY Advanced Science Research Center and is an Einstein Professor of Chemistry & Biochemistry at the City College of New York. After training with Joe Coleman and Lewis Kay, he has led an academic structural biology group using NMR to study ways to naturally and artificially control proteins, aiming to provide new insights and tools for research and therapeutic purposes.

Reference-free Quantitative NOE and the Structural Value of Two-bond (2JCH) Coupling Constants for Configurational Analysis of Small Molecules

Roberto is the Research Professor and Director of the NMR Center of the Department of Chemistry at CMU. Since 2008 he has been involved in the development of new methodologies for the structural analysis of small molecules using a combination of isotropic and anisotropic NMR parameters together with computational methods. He has developed together with Prof. Armando Navarro-Vazquez the unique computational method “Computer Assisted 3D Structure Elucidation” (CASE-3D). In 2012 he was the Program Chair of SMASH-NMR, and he is currently emeritus member of the SMASH organizing committee. In 2012 he also edited a special supplementary issue for the journal Magnetic Resonance in Chemistry (MRC) on “NMR of Small Molecules in Anisotropic Media.”

Monitoring Hydrogel Swelling Using Unilateral NMR

Daniel Gruber received his Ph.D. in Chemical Physics with the Augustine Group at UC Davis studying design and methodology for low-field, single-sided NMR. He is now a postdoctoral researcher in the Magnetic Imaging Group at NIST in Boulder, CO.

Speedy and Robust Quantitative Analysis using Generic QA-RINEPT: From Small Molecules to Polymeric Materials

Dr. Hou received his Ph.D. from Virginia Tech. His focus is on developing NMR methodologies for polymer characterization, such as transport in polymers, speedy and robust quantitative spectroscopy, and spectroscopic separation by NMR diffusometry.

When is a peak, a peak?

Undergraduate work in chemistry at the University of Rochester; Graduate work in chemistry at Columbia University with Ruben Gonzalez; currently an assistant professor in chemistry at Rutgers University-Newark.

Signal to Noise in Time-Domain

Krish Krishnamurthy’s (Independent researcher, Chempacker LLC) interest is in pulse sequence development and time-domain data processing in small molecule NMR. He is the recipient of 2018 James Shoolery award in recognition of his life-time contribution to the field of small molecule NMR.

An NMR-based metabolomic view of the natural history of COVID-19 disease

Group leader of the Precision Medicine and Metabolism laboratory of CIC bioGUNE. I am interested in the NMR-based metabolomics of biofluids for the diagnose of rare and prevalent diseases.

NMR Characterization of Polyphosporylation Reactions in Low Complexity Domain Proteins

Dr. Mirau uses NMR spectroscopy to study polymers and biopolymers. Current research topics include the reactivity in protein-inorganic composites, the structure of DNA aptamers and cell-free protein synthesis.

Facilitated structure verification of therapeutic peptides from 2D heteronuclear maps acquired at natural abundance

I am an NMR Scientist at United States Pharmacopeia involved in structure verification of peptides and chemical medicines. I graduated from Georgia State University and did my postdoctoral work at Johns Hopkins University in Biophysics, Structural Biology and NMR method development.

Structure and Molecular Dynamics of Semicrystalline Polymers as Explored by Solid State NMR Spectroscopy

Toshikazu Miyoshi obtained his Ph.D in Chemistry (1997) at Kyoto University, Japan. After postdoctoral work at Institute of Polymer Research Dresden, Germany, he joined National Institute of Advanced Technology and Industrial Science in 2000. He joined The University of Akron, as an associate professor in 2010 and was promoted to Full Professor in 2018. His research interests include developments of solid-state NMR techniques and their application to semi-crystalline and glassy polymers, carbon materials, self-assembly, and biomaterials.

NMR in the chemical warehouse: Development of rapid identification testing procedures with benchtop instrumentation.

Ph.D. in Chemistry from Universidad de La Laguna (Spain) in 2010, followed by postdoctoral work at University of Illinois at Chicago (2010-2013). NMR professional working in Pharma R&D for AbbVie (2013-2019) and Genentech (2019-present).

GEMSTONE: ultra-selective NMR methods for fast analysis of complex spectra

PhD from Swedish University of Agricultural Sciences (1999). Lecturer (2012), Reader (2013) and Professor (2018) of Physical Chemistry at the University of Manchester. My research interest includes the development of novel methods in liquids NMR.

LED-NMR: A Practical Tool for Shining Light on Photochemical Reactions

Ph.D. level scientist with 15 years of scientific experience in the pharmaceutical industry. Have been
involved in almost all stages of a pharmaceutical pipeline, from early discovery to late development.
Through collaborative work, gained expertise in Discovery, Process, and Analytical Chemistry, as
well as Formulation, for small and large molecule modalities. Scientific leadership; expert in NMR,
both small and large molecules.

Quantitative NMR Determination of PLGAs Molecular Weight and Lactic/Glycolic Ratio

Yixin Ren received his Ph.D. degree in polymer chemistry at the University of Texas at Dallas in 2019. After his graduation, Ren completed a 3-years post-doc appointment at the Wright-Patterson Air Force Research Laboratory (AFRL). As a research scientist at AFRL, his research focused on photo-thermal response polymer synthesis and characterization, and structure to property relationship. Ren is a Scientist III in the Product Quality & Analytical Method division of Digital & Innovation Department, leading the Polymer Characterization incubation project. His current work will focus on (1) development of standard methods for the analysis and evaluation of bioresorbable polymers (2) standardization of polymer database & Exploration of potential digital applications, and (3) investigation of polymer applications in advanced manufacturing technologies.

A new approach for automated qNMR data analysis

Ben joined USP in 2020 and is responsible for the development of qNMR and other digital and analytical products and applications for R&D, quality control, process chemistry and analytical chemistry. Prior to joining USP, Ben was a Senior Product Manager at Mettler-Toledo Autochem where he was responsible for particle characterization process analytical technology (PAT) and he developed EasyViewer and iC Vision product lines. Ben holds a Bachelor of Science degree in chemical engineering and a Master of Science degree in materials science and engineering from the University of Maryland in College Park. Ben is currently pursuing an MBA from The Johns Hopkins University Carey Business School.

Dual Q, Actively Controlled RF Coil for Improved Signal Detection at Low Magnetic Fields

Karl Stupic is a research scientist in the Magnetic Imaging Group at NIST-Boulder. His research focuses on novel contrast agent development, low field magnetic resonance, instrument development, and standards for magnetic resonance.

Proposed revision to the USP NMR General Chapter <1761>

Dr. Christina Szabo is currently Associate Director of Research at Baxter Healthcare. She has been aligned with the Renal Care business of Baxter since 2018 and leads Renal R&D Analytical Chemistry and Stability. Prior to that she was Director of Research of Advanced Chemistry and Investigations in the Corporate Analytical Center of Excellence that supported investigations and changes to existing products and development of new products for all of Baxter’s businesses by application of Nuclear Magnetic Resonance and Mass Spectrometry, Extractables and Leachables, and Elemental Impurities.

Water proton nuclear magnetic resonance for vaccine and gene therapy product characterizations

Dr. Taraban received his M.S. in Physical Chemistry and Ph.D. in Chemical Physics/Biophysics. He is interested in applications of low-field time-domain NMR to analyze stability and quality of drug products noninvasively in their original containers.

Application of software solution to further develop benchtop NMR as a viable PAT

Jiayu completed his B.S. in Chemistry at Rutgers University in 2019, and a M.Sc. in Chemical Engineering at Columbia University in 2021. During his master’s study, he focused on probabilistic modeling and data analysis for enhanced enzyme diffusion. During the same time period, he found interest in areas such as experiment design and automated experimentation, which eventually motivated him to join Professor Hein’s lab at UBC. In his spare time, he enjoys playing video games, biking, and playing ultimate Frisbee.

Long-Chain Branch Detection and Quantification in Ethylene-Hexene LLDPE with New 13C NMR Pulse Sequences

Zhe Zhou obtained Ph.D. in Kyoto University of Japan. In 2016 he was awarded the highest honor to Dow Analytical chemist – Vernon Stenger Scientists’ Award for his meritorious achievement. His current research focuses are polyolefin microstructures.