Juan Araneda – Quantification of Lithium using Lithium-7 qNMR
By Juan Araneda Lithium is used in many industrial manufacturing processes such as glass, ceramics, lubricating grease, and pharmaceuticals. However, its importance in the last two decades has increased due in part to the superior performance of lithium-ion batteries,...
Adolfo Botana – Practical aspects of 13C qNMR
By Adolfo Botana Quantitative NMR is one of the most important tools for the quantification of chemical species in samples. It is most commonly run through the measurement of 1H detected single pulse experiments, but severe spectral overlap makes the quantification of...
Henry Enninful – Improved NMR Cryoporometry of a Strongly Disordered Porous Material
By Henry Enninful Fluid phase transitions in pores offer an important tool for pore space characterization. Alterations in the properties of fluids under confinement provide markers for the quantitative analysis of pore sizes. By the well-known Gibbs-Thomson and...
Christoph Freudenberger – Application of Quality by Design principles to the development qNMR methods
By Christoph Freudenberger Recently published guidelines from e.g. USP, Eurachem/CITAC, ICH and ISO demonstrate that the principles of Quality by Design (QbD), which are frequently in the pharmaceutical and biopharmaceutical industries to drive process development and...
Navin Kafle – Developing Next Generations of Polyolefins for Sustainability Assisted by Solid-State NMR
By Navin Kafle Solid-state (ss) NMR spectroscopy is the one important characterization tool to understand molecular dynamics, molecular interaction, and phase structure of semicrystalline and glassy polymers in bulk systems. Anisotropic chain dynamics1 leads to higher...
Diganta Kalita – Molecular Interaction of Caffeine and Chlorogenic Acid in Coffea arabica Whole Coffee Cherries Extracts by NMR Spectroscopy
By Diganta Kalita Caffeine and chlorogenic acids are two major bioactive compounds available in coffee cherry which offers health beneficial effects to human. However, US Food and Drug Administration recommends caffeine to be safer within a limit of consumption with...
Maxwell Marple – Detection of Degradation in Polymers for Carbon Capture Applications
By Maxwell Marple Aminopolymers are promising sorbent materials for direct air capture applications demonstrating efficient adsorption of atmospheric CO2 that can then be regenerated by exposure to elevated temperatures and steam. During regeneration the CO2 is...
Michele Martin – Using Single-Sided NMR to Monitor the Curing of 3D Printed Resin
By Michele Martin As magnetic resonance techniques continue to be adapted for a wide range of industrial, agricultural, and medical applications, the development of custom reference objects that ensure properly functioning equipment and processing techniques is...
Klas Meyer – Compact NMR Spectroscopy in the field: A Versatile PAT Tool for Production of Specialty Chemicals
By Klas Meyer Companies of chemical industry find themselves more often in a rapidly changing environment, e.g., due to variability of raw material quality or energy costs and efficiency. Process optimization and new process concepts become more and more important....
Toshikazu Miyoshi – Elucidations of Complex Chemical Reactions of Carbon Fiber Precursors by Sensitivity Enhanced Solid-state NMR
By Toshikazu Miyoshi Polyacrylonitrile (PAN) is an important industrial polymer material because it is precursor for carbon fiber. Heat-treatment induces strucutral change from linear polymer chains to three dimensional carbon materials which determine final...
Arvin Moser – Searching Libraries of Known Structures for Dereplication: Benefits and Requirements
By Arvin Moser A very important question that natural products chemists face is whether the newly isolated compound they have is truly novel or already known. This process, commonly referred to as dereplication, is also performed by people doing competitive product...
Ben Reiner – Programming the Intensity of Small Molecule Signals in Complex Formulations Through Bespoke Non- Uniform Sampling Schedules
By Ben Reiner Functional polymers are a key feature of complex formulations across a wide class of material science disciplines. However, the presence of small molecule or oligomeric impurities can often convolute spectral analysis. Nuclear magnetic resonance (NMR)...
Pablo Trigo Mourino – NMR Tools for the Assessment of Antibody-Drug Candidates Aggregation State
By Pablo Trigo Mourino Discovery & development of monoclonal antibodies and other biologic therapeutics relies heavily on analytical methods to capture molecular attributes, assess development risks, and optimize complex drug substance mixtures. With many methods to...
Xu Qiuwei – Characterization of Mitochondrial PolgD257A Mutant Mouse using NMR Metabolomics
By Xu Qiuwei Mitochondria are important for bioenergetics and critical sources of biosynthetic pathways including amino acid, urea, heme, and bile acid. Mitochondrial dysfunction is often a cause of many human diseases including neuronal Parkinson’s disease....
Yixin Ren – Quantitative NMR Determination of PLGAs Molecular Weight and Lactic/Glycolic Ratio
By Yixin Ren The biodegradable and biocompatible co-polymer poly(lactide-co-glycolide) (PLGA) comprises various ratios of its monomers: lactide and glycolide (L&G), and used extensively in biomedical applications such as drug delivery and tissue engineering...
Cameron Robertson – New Product development; from the what to the why
By Cameron Robertson Consumer health products are becoming more important in our everday lives and the increasing use of these products has led Industry to know, not only how well a new formulation works, but why it works. Our academic research group (KASNMR) have...
Aritra Sarkar – Flow NMR and its application in process monitoring and drug development
By Aritra Sarkar Flow NMR has emerged as an important analytical technology for process monitoring over the last decade. Recent advancements in flow cell technologies have enabled access to commercially available, online monitoring setups that can be easily fitted to...
Cole Tower – Predicting Stability of Lyophilized Protein Formulations using Solid State NMR
By Cole Tower Many protein drugs must be formulated in the solid state, typically via lyophilization with a disaccharide, to maintain adequate stability during storage. Two theories exist to explain why a disaccharide stabilizes the protein: the vitrification theory...
Sirvan Sultan Uguz – Exploring the Correlation of LF NMR Relaxation with the Composition Based Glass Transition
By Sirvan Sultan Uguz Hard candies produced by sucrose and doctoring agents such as glucose syrup (GS) and high fructose corn syrup (FS) have been investigated in terms of their final composition, glass transition temperature (Tg), degree of crystallinity, total...
Jose Uribe – Automation and Additive Manufacturing Techniques in the ssNMR Maker Space
By Jose Uribe Achieving homogenous radiofrequency (rf) magnetic fields in solid-state NMR transceiver coils is crucial for maximizing sensitivity during experimentation. Methods to measure coil homogeneity successfully and accurately have been a time-consuming and...
Joseph Vasquez – Quantitative Comparison of 13C Spectra Acquired Using a New Adiabatic Anti-Ring Pulse Sequence to the Conventional Inverse-Gated Decoupling Single Pulse Experiment
By Joseph Vasquez 13C Nuclear Magnetic Resonance (NMR) is traditionally considered an insensitive technique, requiring long acquisition times to measure dilute functionalities on large polymers. With the introduction of cryoprobes and better electronics, sensitivity...
Flynn Watson – Automated Quantitation of Taste Active Metabolites in Wine
By Flynn Watson Proline is typically the most abundant amino acid present in wine however, it has historically been overlooked as it’s not consumed by yeast. Proline itself is known to be sweet though it’s impact in wine has been scarcely studied despite it being...
Yicheng Cassie Yang – Towards the development of rapid, automated identification tests for neat organic liquids using benchtop NMR instrumentation.
By Yicheng Cassie Yang The advent of benchtop NMR instrumentation has paved the way for the use of this technology away from traditional NMR facility settings. Still, a wider adoption of benchtop NMR for routine identification testing has been hampered by inherent...
Jin Kim Young – Interleaved Magnetoencephalography and Magnetic Resonance Imaging with Multichannel Atomic Magnetometers
By Jin Kim Young Magnetic resonance imaging (MRI) in the ultra-low field (ULF) regime (
Hong Zhuang – Relationship between water-holding capacity and T2 parameters in poultry breast meat
By Hong Zhuang Water-holding capacity (WHC) is an indicator of the ability of meat to retain its own and/or added water under external influences. It directly influences meat quality. 1H-NMR has been shown as an accurate and fast method for determination of water in...
Marc Taraban – Variable Temperature Low-Field TD NMR—Novel Applications to Emulsion Drug Products
By Marc Taraban Variable temperature time-domain benchtop NMR (VT-NMR) instrument with attainable temperature range from -70 °C to +80 °C allows to perform the measurements not only at a fixed temperature value but is also capable to scan the temperature in the above...