By Marc Taraban
Although water played a critical role in the early development of NMR, it is typically considered unwanted background to be removed or suppressed in contemporary NMR spectroscopy. Water, as the solvent, has extensive interactions with solutes dissolved or suspended in it. Such interactions form the basis of using the 1H2O NMR signal to probe the physicochemical status of the solutes. We have applied this technology, termed wNMR, to characterize biologics and other complex drugs. Compared with conventional analytical techniques, wNMR has the distinct advantage of being completely noninvasive. This presentation will discuss our latest work on using wNMR characterize marketed vaccines and gene therapy products under development.
Session #9: Proteins, Peptides, Genes/Vaccines – With our Magnets Now You’re Seen