Samuel Kotler is a research scientist in the Division of Preclinical Innovation (DPI) at the National Center for Advancing Translational Sciences (NCATS). Sam works as an NMR spectroscopist in the Analytical Chemistry Core (ACC) where he applies various NMR methodologies to study small molecule structure and dynamics as well as protein-ligand interactions, applying his findings to develop novel chemical probes and therapeutics. Prior to working at NIH, Sam obtained is Ph.D. in Biophysics from the University of Michigan-Ann Arbor. As a PhD student working in the lab of Ayyalusamy Ramamoorthy, he worked on characterizing the structural and dynamic self-assembly processes of the Alzheimer’s amyloid-beta peptide. Then, he joined the lab of Marius Clore at NIDDK as an NIGMS PRAT Fellow. His research in the Clore lab focused on Huntington’s disease, a fatal neurological disorder arising from polyglutamine expansion within the huntingtin protein. He demonstrated huntingtin undergoes initial multimerization events occurring on the sub-millisecond timescale and involve sparsely populated species that can be probed at atomic resolution by NMR. In his free time, Sam enjoys hiking, cycling, camping, painting miniatures, and being a father.
Samuel A. Kotler Bio
