Previous research applied SHARPER sequences at high field (400 MHz) to a range of reactions and showed the benefits for reaction monitoring in inhomogeneous magnetic fields, for example those caused by gas bubbling.1 Further work adapted the sequence to measure multiple signals of interest simultaneously, e.g. a product and reactant.[2] The sequences have been adapted for compatibility with benchtop NMR systems.[3] This presentation shows the sensitivity benefits of simultaneous decoupling of all nuclei when studying nuclei from phosphorus-31 to silicon-29 at 60 MHz, as well as future extensions of the technique.
References
[1] Jones, A. B.; Lloyd-Jones, G. C.; Uhrín, D., Anal. Chem., 89(18), 10013-10021, 2017.
[2] Davy, M; Dickson, C. L.; Wei, R; Uhrín, D; Butts, C. P., Analyst, 147, 1702-1708, 2022.
[3] Dickson, C. L.; Peat, G; Rossetto, M; Halse, M. E.; Uhrín, D., Chem. Commun., 2022,
https://doi.org/10.1039/D2CC01325H.