The pharmaceutical landscape is rapidly changing and nowadays the therapeutic arsenal includes small molecules (MW 300-500 Da), therapeutic oligonucleotides (MW 6 to 18 kDa), mAbs (MW 150 kDa) and polysaccharide/mRNA vaccines.
Analytical techniques (NMR, MS, LC …) have to be able to cope with these new compounds and to provide relevant structural information. The full characterization of these molecules by NMR is not always possible but a fingerprint can be obtained using different nuclei.
In this webinar, we will show how high field NMR can be used to study RNA molecules and therapeutic oligonucleotide analogs. The versatility of modern NMR probes allows to probe the structure of these molecules using a collection of different nuclei (1H, 13C, 15N, 31P and 19F).